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The presence of a bezoar is a relatively infrequent disorder that affects the gastrointestinal system. It consists of a solid and formed mass trapped in the gastrointestinal system, usually in the stomach.〔 These can also form in other locations. Gastric phytobezoars are a form of intestinal blockage and are seen in those with poor gastric motility. The preferred treatment of bezoars includes different therapies and/or fragmentation to avoid surgery. Phytobezoars, are most common and consist undigested, lignin, cellulose, and tannin, celery, pumpkins, grape skins, prunes, raisins, vegetables and fruits〔Iwamuro, M., Okada, H., Matsueda, K., Inaba, T., Kusumoto, C., Imagawa, A., & Yamamoto, K. (2015). Review of the diagnosis and management of gastrointestinal bezoars. World Journal of Gastrointestinal Endoscopy, 7(4), 336–345. doi:10.4253/wjge.v7.i4.336〕 Phytobezoars can form after eating persimmons and pineapples. These are more difficult to treat and are referred to as diospyrobezoars.〔 Coca-Cola has been proposed for the treatment of gastric phytobezoars. In about 50% of cases studied, Coca-Cola alone was found to be effective in gastric phytobezoar dissolution. Unfortunately, this treatment can result in the potential of developing small bowel obstruction in a minority of cases, necessitating surgical intervention.〔 It is one of many other stomach disorders that can have similar symptoms.〔(【引用サイトリンク】publisher=Healthline )〕 == History and medical uses == Coca-Cola has a long history of medical uses. It was first used as substitute for morphine by Confederate Colonel John Pemberton. He had become addicted to morphine after being wounded in the Civil War and was intent on finding a substitute.〔Richard Gardiner, “The Civil War Origin of Coca-Cola in Columbus, Georgia,” ''Muscogiana: Journal of the Muscogee Genealogical Society'' (Spring 2012), Vol. 23: 21–24.〕 The first Coca-Cola recipe was created at Pemberton's own Eagle Drug and Chemical House, in Columbus, Georgia and originally marketed as a coca wine.〔(【引用サイトリンク】title=Coca Cola Inventor was Local Pharmacist )〕〔(【引用サイトリンク】publisher= Columbus Ledger Enquirer )〕 In response to the passage of local prohibition laws passed in 1886, Pemberton then changed the composition and created a nonalcoholic version of his coca wine. This newly formulated version was sold in his store and marketed as a patent medicine for five cents per glass at his store's soda fountains, which were becoming more numerous at the time because of the belief that carbonated water was good for the health. Pemberton advertised that Coca-Cola cured many diseases, including morphine addiction, dyspepsia, neurasthenia, headache, and impotence. By 1888 production had increased along with medical claims. In April 1888, a druggist Asa Griggs Candler, purchased a one-third interest in the formula of the proprietary elixir known as Coca-Cola. A phytobezoar was first successfully treated with Coca-Cola lavage in 2002.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Coca-Cola treatment of phytobezoars」の詳細全文を読む スポンサード リンク
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